Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis | Zendy

Achilles Ntranos | Zendy; Vasilis Ntranos | Zendy; Valentina Bonnefil | Zendy; Jia Liu | Zendy; Seunghee KimSchulze | Zendy; Ye He | Zendy; Yunjiao Zhu | Zendy; Rachel Brandstadter | Zendy; Corey T. Watson | Zendy; Andrew J. Sharp | Zendy; Ilana Katz Sand | Zendy; Patrizia Casaccia | Zendy

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Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis

Author(s) -

Achilles Ntranos,

Vasilis Ntranos,

Valentina Bonnefil,

Jia Liu,

Seunghee KimSchulze,

Ye He,

Yunjiao Zhu,

Rachel Brandstadter,

Corey T. Watson,

Andrew J. Sharp,

Ilana Katz Sand,

Patrizia Casaccia

Publication year - 2018

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awy344

Subject(s) - multiple sclerosis , epigenetics , downregulation and upregulation , homing (biology) , cytotoxic t cell , microrna , immunology , cancer research , biology , neuroscience , medicine , genetics , gene , in vitro , ecology

Fumarates are effective immunomodulators in multiple sclerosis but their mechanism of action remains elusive. Ntranos et al. show that the immunomodulatory effect of fumarates is due to epigenetic regulation of brain-homing T cells. Treatment with fumarates leads to hypermethylation of microRNA-21, preventing its upregulation in encephalitogenic T-helper and T-cytotoxic cells.

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