Microglial phenotypes in the human epileptic temporal lobe | Zendy

Mélanie MorinBrureau | Zendy; Giampaolo Milior | Zendy; Juliette Royer | Zendy; Farah Chali | Zendy; Caroline Le Duigou | Zendy; Etienne Savary | Zendy; Corinne Blugeon | Zendy; Laurent Jourdren | Zendy; David Akbar | Zendy; Sophie Dupont | Zendy; Vincent Navarro | Zendy; Michel Baulac | Zendy; Franck Bielle | Zendy; Bertrand Mathon | Zendy; Stéphane Clémenceau | Zendy; Richard Miles | Zendy

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Microglial phenotypes in the human epileptic temporal lobe

Author(s) -

Mélanie MorinBrureau,

Giampaolo Milior,

Juliette Royer,

Farah Chali,

Caroline Le Duigou,

Etienne Savary,

Corinne Blugeon,

Laurent Jourdren,

David Akbar,

Sophie Dupont,

Vincent Navarro,

Michel Baulac,

Franck Bielle,

Bertrand Mathon,

Stéphane Clémenceau,

Richard Miles

Publication year - 2018

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awy276

Subject(s) - temporal lobe , neuroscience , epilepsy , phenotype , psychology , biology , biochemistry , gene

Using transcriptomics, anatomical studies, imaging and ELISA, Morin-Brureau et al. examine microglia in patients with temporal lobe epilepsies. In highly sclerotic regions such as CA1, the anti-inflammatory cytokine IL-10 regulates microglial phenotype. Seizures induce a transient microglial phenotype associated with secretion of inflammatory cytokines including human CXCL8.

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