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Sir,Heat shock proteins (HSPs) are protein chaperones that play important roles in maintaining protein homeostasis. Ours and others’ research have shown that DNAJB2a (encoded by DNAJB2 ) is capable of resolving aggregates caused by TDP-43 (Chen et al. , 2016), SOD1 (Novoselov et al. , 2013; Gess et al. , 2014), huntingtin (Labbadia et al. , 2012) and mutant parkin (Rose et al. , 2011). Given DNAJB2’s neuronal enriched expression, it is not surprising that it shows such effectiveness in resolving the protein aggregates associated with neurodegenerative diseases. The question is, is DNAJB2a the sole protein for that role, and is …

Reply: The role ofDNAJB2in amyotrophic lateral sclerosis