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Sir, We thank Dr Mavridis for this very thoughtful comment about nucleus accumbens atrophy in patients with Parkinson’s disease from a neurosurgical point of view. Indeed it had been previously reported that dopamine loss also occurs in the nucleus accumbens of patients with Parkinson’s disease especially at the advanced stages (Farley et al. , 1977). Different groups, including our own have shown that patients with Parkinson’s disease are affected differently on functions relying on the ventral versus the dorsal striatum …

Reply: Is nucleus accumbens atrophy correlated with cognitive symptoms of Parkinson’s disease?