Open AccessReply: Retinopathy, histidine-rich protein-2 and perfusion pressure in cerebral malaria
Author(s) -
Ian J. C. MacCormick,
Nicholas A. V. Beare,
Terrie E. Taylor,
Valentina Barrera,
Valerie A. White,
Paul Hiscott,
Malcolm E. Molyneux,
Baljean Dhillon,
Simon Harding
Publication year - 2014
Publication title -
brain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.142
H-Index - 336
eISSN - 1460-2156
pISSN - 0006-8950
DOI - 10.1093/brain/awu146
Subject(s) - cerebral malaria , retina , neurovascular bundle , cerebral autoregulation , autoregulation , cerebral perfusion pressure , neuroscience , cerebral circulation , medicine , biology , ophthalmology , cerebral blood flow , cardiology , malaria , blood pressure , pathology , plasmodium falciparum
Sir, We thank Kariuki and Newton for their letter which raises several interesting points. We value their contributions to this discussion.Failure of cerebral autoregulation may be an important step in the cerebral malaria disease process. Ideally our review would have not only included comparisons of autoregulatory function in retinal and cerebral vessels, but also other important subjects such as the nature of the blood-tissue barriers, distribution of endothelial receptors, and vessel ultrastructure in retina and brain. Comparing and contrasting the retina with other areas of the CNS in terms of these and other features could well provide valuable insights, not just into cerebral malaria, but for a whole range of neurovascular diseases. We hope our paper will help to …
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