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Sir, We are grateful for the opportunity to respond to the correspondence from Dr He, and we thank the author for his interest in our recent article, which demonstrated that platelet-derived growth factor (PDGF) is secreted by bone marrow-derived mesenchymal stem cells (MSCs) and confers neuroprotection to retinal ganglion cells in organotypic retinal explant culture and in an in vivo model of ocular hypertensive glaucoma (Johnson et al. , 2013). Based on our previously reported observation that intravitreal MSC transplantation confers optic nerve neuroprotection (Johnson et al. , 2010), we recently analysed the human MSC secretome and compared it to that of human fibroblasts using xMAP antibody-based arrays. As Dr He noted, we demonstrated that PDGF-AA secretion from MSCs was >500-fold greater than from fibroblasts, …

Reply: Platelet-derived growth factor-BB may be involved in mesenchymal stem cell secretome-induced neuroprotection of retinal ganglion cells