Open AccessReply: Cerebral microbleeds in familial Alzheimer's disease
Author(s) -
Wiesje M. van der Flier,
Charlotte Cordonnier
Publication year - 2011
Publication title -
brain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.142
H-Index - 336
eISSN - 1460-2156
pISSN - 0006-8950
DOI - 10.1093/brain/awr127
Subject(s) - alzheimer's disease , medicine , disease , neuroscience , cerebral amyloid angiopathy , dementia , psychology , pathology
ARTICLESir, We read with interest the letter from Ryan et al . in response to our article. The authors add interesting information concerning brain microbleeds in Alzheimer’s disease, as they determined the prevalence of brain microbleeds in a set of familial Alzheimer’s disease cases. In a sample of 12 (11 Presenilin 1, one amyloid precursor protein mutations), they observed brain microbleeds in three patients, i.e. a prevalence of 25% (95% confidence interval 9–53%). Despite large confidence intervals, this prevalence is …
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