Reply: Is inhibition of axonal regeneration by astrocytes, in the dorsal part of the spinal cord, regulated by p75 receptor? | Zendy

Angela L. Scott | Zendy; Matt S. Ramer | Zendy

Open Access

Reply: Is inhibition of axonal regeneration by astrocytes, in the dorsal part of the spinal cord, regulated by p75 receptor?

Author(s) -

Angela L. Scott,

Matt S. Ramer

Publication year - 2010

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awq020

Subject(s) - neurotrophin , low affinity nerve growth factor receptor , trk receptor , receptor , neuroscience , tropomyosin receptor kinase c , biology , microbiology and biotechnology , tropomyosin receptor kinase a , nerve growth factor , schwann cell , neurotrophin 3 , spinal cord , neurotrophic factors , brain derived neurotrophic factor , platelet derived growth factor receptor , growth factor , genetics

ARTICLEThe p75 neurotrophin receptor is a binding or signalling partner for a long list of receptors and ligands. In neurons, p75 neurotrophin receptor expression regulates the binding affinity between Trk receptors and growth-promoting neurotrophins, as well as their binding specificity (Roux and Barker, 2002). Neuronal p75 neurotrophin receptor also transduces growth inhibition conferred by myelin-derived proteins (McGee and Strittmatter, 2003). These cis interactions are much better understood than those occurring in trans , which may be equally important where glial cells, such as Schwann cells in peripheral nerves, express p75 neurotrophin receptor at high levels. A hypothesized trans role for Schwann cell p75 neurotrophin receptor in peripheral nerve regeneration involves its ‘presentation’ of neurotrophins (themselves produced …

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