Hypocretin (orexin) loss and sleep disturbances in Parkinson's Disease | Zendy

Rolf Fronczek | Zendy; Sebastiaan Overeem | Zendy; S. Y. Y. Lee | Zendy; Ingrid M. Hegeman | Zendy; Jos van Pelt | Zendy; Sjoerd G. van Duinen | Zendy; Gert Jan Lammers | Zendy; Dick F. Swaab | Zendy

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Hypocretin (orexin) loss and sleep disturbances in Parkinson's Disease

Author(s) -

Rolf Fronczek,

Sebastiaan Overeem,

S. Y. Y. Lee,

Ingrid M. Hegeman,

Jos van Pelt,

Sjoerd G. van Duinen,

Gert Jan Lammers,

Dick F. Swaab

Publication year - 2007

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awm222

Subject(s) - orexin , parkinson's disease , sleep (system call) , orexin a , neuroscience , psychology , warrant , medicine , disease , computer science , neuropeptide , economics , receptor , operating system , financial economics

We would like to thank Baumann et al . for their interest in our paper (Fronczek et al. , 2007). The questions raised are all relevant and mainly entail the relationship between the partial hypocretin loss in PD (Fronczek et al. , 2007; Thannickal et al. , 2007) and actual sleep disturbances. Furthermore, the selectivity of the hypocretin cell loss in PD is questioned. We fully agree with these remarks and therefore prominently discussed them in our original paper (Fronczek et al. , 2007). However, two of the issues warrant …

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