Complexities in the association of human blood brain barrier disruption with seizures: importance of patient population and method of disruption | Zendy

Tracy Butler | Zendy

Open Access

Complexities in the association of human blood brain barrier disruption with seizures: importance of patient population and method of disruption

Author(s) -

Tracy Butler

Publication year - 2007

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awm119

Subject(s) - blood–brain barrier , epilepsy , temporal lobe , neuroscience , population , mannitol , medicine , status epilepticus , anesthesia , psychology , central nervous system , chemistry , environmental health , organic chemistry

In “Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy” (van Vliet et al ., 2007), the authors found that osmotic opening of the blood–brain barrier (BBB) resulted in transient or permanent increased seizure frequency in chronically epileptic rats. They relate these results to findings in humans that osmotic BBB opening using mannitol induces seizures in patients with brain …

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