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In “Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy” (van Vliet et al ., 2007), the authors found that osmotic opening of the blood–brain barrier (BBB) resulted in transient or permanent increased seizure frequency in chronically epileptic rats. They relate these results to findings in humans that osmotic BBB opening using mannitol induces seizures in patients with brain …

Complexities in the association of human blood brain barrier disruption with seizures: importance of patient population and method of disruption