Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease | Zendy

Jan Herzog | Zendy; Peter H. Weiss | Zendy; A. Assmus | Zendy; B. Wefer | Zendy; C. Seif | Zendy; P. Braun | Zendy; Herbert Herzog | Zendy; Jens Volkmann | Zendy; Günther Deuschl | Zendy; Gereon R. Fink | Zendy

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Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease

Author(s) -

Jan Herzog,

Peter H. Weiss,

A. Assmus,

B. Wefer,

C. Seif,

P. Braun,

Herbert Herzog,

Jens Volkmann,

Günther Deuschl,

Gereon R. Fink

Publication year - 2006

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awl302

Subject(s) - subthalamic nucleus , deep brain stimulation , parkinson's disease , medicine , stimulation , neuroscience , central nervous system disease , psychology , disease , surgery

Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective therapy for off-period motor symptoms and dyskinesias in advanced Parkinson's disease. Clinical studies have shown that STN-DBS also ameliorates urinary bladder function in Parkinson's disease patients by delaying the first desire to void and increasing bladder capacity. This study aimed at investigating the effect of STN-DBS on the neural mechanisms underlying cerebral bladder control. Using PET to measure changes in regional cerebral blood flow (rCBF), 11 patients with bilateral STN-DBS were studied during urodynamic bladder filling in STN-DBS ON and OFF condition. A filled bladder led to a significant increase of rCBF in the anterior cingulate cortex, which was further enhanced during STN-DBS OFF. A significant interaction between bladder state and STN-DBS was observed in lateral frontal cortex with increased rCBF when the bladder was filled during STN-DBS OFF. The data suggest that STN-DBS ameliorates bladder dysfunction and that this modulation may result from facilitated processing of afferent bladder information.

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