The optic nerve: a new window into cerebrospinal fluid composition? | Zendy

Hanspeter E. Killer | Zendy; Gregor P. Jaggi | Zendy; Josef Flammer | Zendy; Neil R. Miller | Zendy; Andreas Huber | Zendy

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The optic nerve: a new window into cerebrospinal fluid composition?

Author(s) -

Hanspeter E. Killer,

Gregor P. Jaggi,

Josef Flammer,

Neil R. Miller,

Andreas Huber

Publication year - 2006

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awl045

Subject(s) - cerebrospinal fluid , compartment (ship) , subarachnoid space , lumbar puncture , pathology , fluid compartments , medicine , lumbar , optic nerve , homogeneous , anatomy , chemistry , extracellular fluid , extracellular , biochemistry , oceanography , physics , geology , thermodynamics

Cerebrospinal fluid (CSF) pressure and composition are generally thought to be homogeneous within small limits throughout all CSF compartments. CSF sampled during lumbar puncture therefore should be representative for all CSF compartments. On the basis of clinical findings, histology and biochemical markers, we present for the first time strong evidence that the subarachnoid spaces (SAS) of the optic nerve (ON) can become separated from other CSF compartments in certain ON disorders, thus leading to an ON sheath compartment syndrome. This may result in an abnormal concentration gradient of CSF molecular markers determined in locally sampled CSF compared with CSF taken during lumbar puncture.

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