Open AccessThe microglial component of amyotrophic lateral sclerosis
Author(s) -
Benjamin Clarke,
Rickie Patani
Publication year - 2020
Publication title -
brain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.142
H-Index - 336
eISSN - 1460-2156
pISSN - 0006-8950
DOI - 10.1093/brain/awaa309
Subject(s) - microglia , amyotrophic lateral sclerosis , neuroscience , context (archaeology) , neuroprotection , neurodegeneration , multiple sclerosis , disease , biology , medicine , immunology , pathology , inflammation , paleontology
Clarke and Patani review the involvement of microglia in ALS, focusing specifically on evidence for spatiotemporally regulated neurotoxic and neuroprotective roles. Understanding how microglia contribute to the ‘cellular phase’ of ALS promises to advance the development of therapies with a mechanistic rationale.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom