Towards the reconstruction of central nervous system white matter using neural precursor cells | Zendy

Masato Mitome | Zendy; Hoi Pang Low | Zendy; Anthony van den Pol | Zendy; John J. Nunnari | Zendy; Merrill K. Wolf | Zendy; Susan BillingsGagliardi | Zendy; William J. Schwartz | Zendy

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Towards the reconstruction of central nervous system white matter using neural precursor cells

Author(s) -

Masato Mitome,

Hoi Pang Low,

Anthony van den Pol,

John J. Nunnari,

Merrill K. Wolf,

Susan BillingsGagliardi,

William J. Schwartz

Publication year - 2001

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/124.11.2147

Subject(s) - myelin , white matter , central nervous system , transplantation , biology , myelin basic protein , neuroscience , phenotype , microbiology and biotechnology , pathology , medicine , biochemistry , gene , magnetic resonance imaging , radiology

Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.

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