Open AccessAdvances in the recognition and management of hereditary cancer
Author(s) -
A. Kulkarni,
Helena Carley
Publication year - 2016
Publication title -
british medical bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.08
H-Index - 112
eISSN - 1471-8391
pISSN - 0007-1420
DOI - 10.1093/bmb/ldw046
Subject(s) - cancer , medicine , mendelian inheritance , bioinformatics , genetics , gene , biology
Constitutional mutations in genes controlling DNA repair, cell-cycle regulation and cell apoptosis can determine an individual's tendency to develop cancer. Hereditary cancer predisposition syndromes present with multiple cancers at a young age and underlie a significant burden of morbidity and mortality. Recent advances in the recognition and management of hereditary cancer will be illustrated with specific examples of developments in diagnosis and treatment.
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