Open AccessMouse-based genetic modeling and analysis of Down syndrome
Author(s) -
Zhuo Xing,
Yichen Li,
Annie Pao,
Abigail S. Bennett,
Benjamin Tycko,
William C. Mobley,
Yichao Yu
Publication year - 2016
Publication title -
british medical bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.08
H-Index - 112
eISSN - 1471-8391
pISSN - 0007-1420
DOI - 10.1093/bmb/ldw040
Subject(s) - down syndrome , genetics , computational biology , biology , medicine
Down syndrome (DS), caused by human trisomy 21 (Ts21), can be considered as a prototypical model for understanding the effects of chromosomal aneuploidies in other diseases. Human chromosome 21 (Hsa21) is syntenically conserved with three regions in the mouse genome.
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