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Pathogenesis of amyotrophic lateral sclerosis
Author(s) -
Sarah Morgan,
Richard W. Orrell
Publication year - 2016
Publication title -
british medical bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.08
H-Index - 112
eISSN - 1471-8391
pISSN - 0007-1420
DOI - 10.1093/bmb/ldw026
Subject(s) - amyotrophic lateral sclerosis , c9orf72 , frontotemporal dementia , disease , neuroscience , neurodegeneration , medicine , pathogenesis , dementia , genome wide association study , bioinformatics , pathology , biology , genetics , single nucleotide polymorphism , gene , genotype
Amyotrophic lateral sclerosis (ALS) or motor neuron disease is a rapidly progressive neurodegenerative disorder. The primary involvement is of motor neurons in the brain, spinal cord and peripherally. There is secondary weakness of muscles and primary involvement of other brain regions, especially involving cognition.

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