Wire- and magnetic-seed-guided localization of impalpable breast lesions: iBRA-NET localisation study | Zendy

Rajiv Dave | Zendy; Emma Barrett | Zendy; Jenna Morgan | Zendy; Mihir Chandarana | Zendy; Suzanne Elgammal | Zendy; Nicola Barnes | Zendy; Amtul Sami | Zendy; Tahir Masudi | Zendy; Sue Down | Zendy; Chris Holcombe | Zendy; Shelley Potter | Zendy; Santosh K. Somasundaram | Zendy; Matthew D. Gardiner | Zendy; Senthurun Mylvaganam | Zendy; Anthony Maxwell | Zendy; James Harvey | Zendy; A. Tanska | Zendy; Anna Hurley | Zendy; Astrid Leusink | Zendy; Edward St John | Zendy; Ilaria Giono | Zendy; K Shanthakunalan | Zendy; Kathryn E. Harborough | Zendy; Karyn Shenton | Zendy; Noa Gonen | Zendy; Qurrat Ul Ain | Zendy; P. R. O’Connell | Zendy; Rebekah Law | Zendy; Victoria Teoh | Zendy; Ziao Yan | Zendy; A. Gaber Eltatawy | Zendy; Tim Rattay | Zendy; Aikaterini Micha | Zendy; Michael Faheem | Zendy; Alexandra Tenovici | Zendy; Chwanrow Baban | Zendy; Gehad Ahmed | Zendy; Mugdha Joshi | Zendy; Kaiyumars Contractor | Zendy; M Charalambous | Zendy; M. Kharashgah | Zendy; M. Hanief | Zendy; A. Milica | Zendy; Aadil Khan | Zendy; Ashleigh Bell | Zendy; Barbara L. Smith | Zendy; Catherine Sproson | Zendy; Ciaran Hollywood | Zendy; Kathryn A. Hodgkins | Zendy; Claire Rutherford | Zendy; Dinesh Thekkinkattil | Zendy; Dhurka Shanthakumar | Zendy; E Rahman | Zendy; Naga Amulya Mullapudi | Zendy; Anna Morad | Zendy; Edel Quinn | Zendy; Fernando Moura | Zendy; Hannah L. Bromley | Zendy; J. Chen | Zendy; Lauren A. Walter | Zendy; Michael A. Preston | Zendy; Nudrat Neyaz | Zendy; Sadaf Jafferbhoy | Zendy; Richard H. Osborne | Zendy; Elaine Borg | Zendy; E. Lumley | Zendy; Kanchana Wijesinghe | Zendy; Friedman Ross | Zendy; Thomas Davies | Zendy; Sian Tovey | Zendy; Hiba Fatayer | Zendy; Ian Whitehead | Zendy; Jo Mondani | Zendy; Karen James | Zendy; Lynn Darragh | Zendy; Tamara Kiernan | Zendy; Uma Sridharan | Zendy; Susan Ashford | Zendy; Siobhan Laws | Zendy; Natalie Robson | Zendy; M. R. A. Matias | Zendy; R. L. Wilson | Zendy; Saadia Ali | Zendy; Muhammad Salman | Zendy; M. Buhleigah | Zendy; Rathinasabapathy Rathinaezhil | Zendy; S. Hignett | Zendy; Timothy Schrire | Zendy; Wm.Osborne Lambert | Zendy

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Wire- and magnetic-seed-guided localization of impalpable breast lesions: iBRA-NET localisation study

Author(s) -

Rajiv Dave,

Emma Barrett,

Jenna Morgan,

Mihir Chandarana,

Suzanne Elgammal,

Nicola Barnes,

Amtul Sami,

Tahir Masudi,

Sue Down,

Chris Holcombe,

Shelley Potter,

Santosh K. Somasundaram,

Matthew D. Gardiner,

Senthurun Mylvaganam,

Anthony Maxwell,

James Harvey,

A. Tanska,

Anna Hurley,

Astrid Leusink,

Edward St John,

Ilaria Giono,

K Shanthakunalan,

Kathryn E. Harborough,

Karyn Shenton,

Noa Gonen,

Qurrat Ul Ain,

P. R. O’Connell,

Rebekah Law,

Victoria Teoh,

Ziao Yan,

A. Gaber Eltatawy,

Tim Rattay,

Aikaterini Micha,

Michael Faheem,

Alexandra Tenovici,

Chwanrow Baban,

Gehad Ahmed,

Mugdha Joshi,

Kaiyumars Contractor,

M Charalambous,

M. Kharashgah,

M. Hanief,

A. Milica,

Aadil Khan,

Ashleigh Bell,

Barbara L. Smith,

Catherine Sproson,

Ciaran Hollywood,

Kathryn A. Hodgkins,

Claire Rutherford,

Dinesh Thekkinkattil,

Dhurka Shanthakumar,

E Rahman,

Naga Amulya Mullapudi,

Anna Morad,

Edel Quinn,

Fernando Moura,

Hannah L. Bromley,

J. Chen,

Lauren A. Walter,

Michael A. Preston,

Nudrat Neyaz,

Sadaf Jafferbhoy,

Richard H. Osborne,

Elaine Borg,

E. Lumley,

Kanchana Wijesinghe,

Friedman Ross,

Thomas Davies,

Sian Tovey,

Hiba Fatayer,

Ian Whitehead,

Jo Mondani,

Karen James,

Lynn Darragh,

Tamara Kiernan,

Uma Sridharan,

Susan Ashford,

Siobhan Laws,

Natalie Robson,

M. R. A. Matias,

R. L. Wilson,

Saadia Ali,

Muhammad Salman,

M. Buhleigah,

Rathinasabapathy Rathinaezhil,

S. Hignett,

Timothy Schrire,

Wm.Osborne Lambert

Publication year - 2021

Publication title -

british journal of surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.202

H-Index - 201

eISSN - 1365-2168

pISSN - 0007-1323

DOI - 10.1093/bjs/znab443

Subject(s) - medicine , radiology , general surgery

Background Wire localization is historically the most common method for guiding excision of non-palpable breast lesions, but there are limitations to the technique. Newer technologies such as magnetic seeds may allow some of these challenges to be overcome. The aim was to compare safety and effectiveness of wire and magnetic seed localization techniques. Methods Women undergoing standard wire or magnetic seed localization for non-palpable lesions between August 2018 and August 2020 were recruited prospectively to this IDEAL stage 2a/2b platform cohort study. The primary outcome was effectiveness defined as accurate localization and removal of the index lesion. Secondary endpoints included safety, specimen weight and reoperation rate for positive margins. Results Data were accrued from 2300 patients in 35 units; 2116 having unifocal, unilateral breast lesion localization. Identification of the index lesion in magnetic-seed-guided (946 patients) and wire-guided excisions (1170 patients) was 99.8 versus 99.1 per cent (P = 0.048). There was no difference in overall complication rate. For a subset of patients having a single lumpectomy only for lesions less than 50 mm (1746 patients), there was no difference in median closest margin (2 mm versus 2 mm, P = 0.342), re-excision rate (12 versus 13 per cent, P = 0.574) and specimen weight in relation to lesion size (0.15 g/mm2versus 0.138 g/mm2, P = 0.453). Conclusion Magnetic seed localization demonstrated similar safety and effectiveness to those of wire localization. This study has established a robust platform for the comparative evaluation of new localization devices.

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