Local peritoneal toxicity from adjuvant pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in high-risk patients with colonic cancer | Zendy

Martin Graversen | Zendy; Sönke Detlefsen | Zendy; Per Pfeiffer | Zendy; Michael Bau Mortensen | Zendy

Open Access

Local peritoneal toxicity from adjuvant pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in high-risk patients with colonic cancer

Author(s) -

Martin Graversen,

Sönke Detlefsen,

Per Pfeiffer,

Michael Bau Mortensen

Publication year - 2021

Publication title -

british journal of surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.202

H-Index - 201

eISSN - 1365-2168

pISSN - 0007-1323

DOI - 10.1093/bjs/znab043

Subject(s) - medicine , oxaliplatin , tolerability , toxicity , adjuvant , chemotherapy , gastroenterology , oncology , colorectal cancer , cancer , adverse effect

This research letter describes unexpected and unacceptable local toxicity manifesting as abdominal pain after adjuvant pressurized intraperitoneal aerosol chemotherapy with 92 mg/m2 oxaliplatin in the PIPAC-OPC3 study. It is not clear whether the toxicity is dose- or drug-dependent (or both), but the preliminary data suggest that tolerability is improved by dose reduction to 46 mg/m2.

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