Genome sequencing of pancreatic cancer: differential expression by location | Zendy

Fengrui Bi | Zendy; Ying Qian | Zendy; Lili Song | Zendy; Hongzhu Qu | Zendy; Junfeng Zheng | Zendy; Xiangdong Fang | Zendy; Tong He | Zendy; Hongli Yan | Zendy

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Genome sequencing of pancreatic cancer: differential expression by location

Author(s) -

Fengrui Bi,

Ying Qian,

Lili Song,

Hongzhu Qu,

Junfeng Zheng,

Xiangdong Fang,

Tong He,

Hongli Yan

Publication year - 2021

Publication title -

british journal of surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.202

H-Index - 201

eISSN - 1365-2168

pISSN - 0007-1323

DOI - 10.1093/bjs/znaa063

Subject(s) - untranslated region , pancreatic cancer , medicine , carcinogenesis , mutation , gene , metastasis , cancer research , genome , three prime untranslated region , cancer , genetics , biology , messenger rna

The results demonstrated that pancreatic ductal carcinoma (PDAC) of the body/tail was associated with more transcriptional and genomic changes, and correlated with worse prognosis, than PDAC of the pancreatic head. The different mutation types and gene expression of tumour locations provide deep insight into the carcinogenesis or metastasis of PDAC, and suggest different early diagnostic and therapeutic strategies. SNV, single-nucleotide variations; NLS, Nuclear localization sequence; MB, million base-pairs; UTR, untranslated region.

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