Single-sample landscape entropy reveals the imminent phase transition during disease progression | Zendy

Rui Liu | Zendy; Pei Chen | Zendy; Luonan Chen | Zendy

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Single-sample landscape entropy reveals the imminent phase transition during disease progression

Author(s) -

Rui Liu,

Pei Chen,

Luonan Chen

Publication year - 2019

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btz758

Subject(s) - entropy (arrow of time) , statistical physics , sample (material) , sample entropy , phase transition , transition (genetics) , statistics , econometrics , mathematics , computer science , biology , chemistry , physics , chromatography , genetics , thermodynamics , gene

The time evolution or dynamic change of many biological systems during disease progression is not always smooth but occasionally abrupt, that is, there is a tipping point during such a process at which the system state shifts from the normal state to a disease state. It is challenging to predict such disease state with the measured omics data, in particular when only a single sample is available.

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