Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations | Zendy

Qian Zhu | Zendy; Xavier Tekpli | Zendy; Olga G. Troyanskaya | Zendy; Vessela N. Kristensen | Zendy

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Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations

Author(s) -

Qian Zhu,

Xavier Tekpli,

Olga G. Troyanskaya,

Vessela N. Kristensen

Publication year - 2019

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btz709

Subject(s) - epigenetics , biology , dna methylation , breast cancer , transcriptional regulation , transcription factor , genetics , computational biology , gene , encode , regulation of gene expression , gene expression , cancer

Breast cancer consists of multiple distinct tumor subtypes, and results from epigenetic and genetic aberrations that give rise to distinct transcriptional profiles. Despite previous efforts to understand transcriptional deregulation through transcription factor networks, the transcriptional mechanisms leading to subtypes of the disease remain poorly understood.

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