Open AccessUnification of miRNA and isomiR research: the mirGFF3 format and the mirtop API
Author(s) -
Thomas Desvignes,
Phillipe Loher,
Karen Eilbeck,
Jeffery Ma,
Gianvito Urgese,
Bastian Fromm,
Jason Sydes,
Ernesto AparicioPuerta,
Víctor Barrera,
Roderic Espín,
Florian Thibord,
Xavier Bofill-De Ros,
Eric Londin,
Aristeidis G. Telonis,
Elisa Ficarra,
Marc R. Friedländer,
John H. Postlethwait,
Isidore Rigoutsos,
Michael Hackenberg,
Ioannis S. Vlachos,
Marc K. Halushka,
Lorena Pantano
Publication year - 2019
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btz675
Subject(s) - computer science , standardization , downstream (manufacturing) , benchmarking , pipeline (software) , ensembl , annotation , computational biology , genomics , biology , operating system , genome , artificial intelligence , engineering , gene , biochemistry , operations management , marketing , business
MicroRNAs (miRNAs) are small RNA molecules (∼22 nucleotide long) involved in post-transcriptional gene regulation. Advances in high-throughput sequencing technologies led to the discovery of isomiRs, which are miRNA sequence variants. While many miRNA-seq analysis tools exist, the diversity of output formats hinders accurate comparisons between tools and precludes data sharing and the development of common downstream analysis methods.
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