MRLR: unraveling high-resolution meiotic recombination by linked reads | Zendy

Peng Xu | Zendy; Timothy Kennell | Zendy; Min Gao | Zendy; Robert P. Kimberly | Zendy; Zechen Chong | Zendy

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MRLR: unraveling high-resolution meiotic recombination by linked reads

Author(s) -

Peng Xu,

Timothy Kennell,

Min Gao,

Robert P. Kimberly,

Zechen Chong

Publication year - 2019

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btz503

Subject(s) - crossover , perl , meiosis , genome , homologous recombination , genotyping , meiotic drive , computational biology , biology , genetics , chromosomal crossover , breakpoint , computer science , genotype , gene , chromosome , artificial intelligence , programming language

Meiotic recombination facilitates the transmission of exchanged genetic material between homologous chromosomes and plays a crucial role in increasing the genetic variations in eukaryotic organisms. In humans, thousands of crossover events have been identified by genotyping related family members. However, most of these crossover regions span tens to hundreds of kb, which is not sufficient resolution to accurately identify the crossover breakpoints in a typical trio family.

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