RBPSponge: genome-wide identification of lncRNAs that sponge RBPs | Zendy

Saber Hafezqorani | Zendy; Aissa Houdjedj | Zendy; Mehmet Arici | Zendy; Abdesselam Said | Zendy; Hilal Kazan | Zendy

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RBPSponge: genome-wide identification of lncRNAs that sponge RBPs

Author(s) -

Saber Hafezqorani,

Aissa Houdjedj,

Mehmet Arici,

Abdesselam Said,

Hilal Kazan

Publication year - 2019

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btz448

Subject(s) - identification (biology) , sponge , genome , computational biology , biology , computer science , genetics , gene , paleontology , botany

Long non-coding RNAs (lncRNAs) can act as molecular sponge or decoys for an RNA-binding protein (RBP) through their RBP-binding sites, thereby modulating the expression of all target genes of the corresponding RBP of interest. Here, we present a web tool named RBPSponge to explore lncRNAs based on their potential to act as a sponge for an RBP of interest. RBPSponge identifies the occurrences of RBP-binding sites and CLIP peaks on lncRNAs, and enables users to run statistical analyses to investigate the regulatory network between lncRNAs, RBPs and targets of RBPs.

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