CNet: a multi-omics approach to detecting clinically associated, combinatory genomic signatures
Author(s) -
Peilin Jia,
Guangsheng Pei,
Zhongming Zhao
Publication year - 2019
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btz441
Subject(s) - genomics , computational biology , categorical variable , genome , computer science , biology , genetics , gene , machine learning
Genome-wide multi-omics profiling of complex diseases provides valuable resources and opportunities to discover associations between various measures of genes and diseases. Currently, a pressing challenge is how to effectively detect functional genes associated with or causing phenotypic outcomes. We developed CNet to identify groups of genomic signatures whose combinatory effect is significantly associated with clinical and phenotypical outcomes.
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