Enhanced Waddington landscape model with cell–cell communication can explain molecular mechanisms of self-organization | Zendy

Hosein Fooladi | Zendy; Parsa Moradi | Zendy; Ali SharifiZarchi | Zendy; Babak Hosein Khalaj | Zendy

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Enhanced Waddington landscape model with cell–cell communication can explain molecular mechanisms of self-organization

Author(s) -

Hosein Fooladi,

Parsa Moradi,

Ali SharifiZarchi,

Babak Hosein Khalaj

Publication year - 2019

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btz201

Subject(s) - multicellular organism , gastrulation , in silico , biology , embryonic stem cell , germ layer , epigenetics , computational biology , self organization , computer science , pattern formation , developmental biology , mechanism (biology) , microbiology and biotechnology , variety (cybernetics) , neuroscience , cell , embryo , artificial intelligence , embryogenesis , genetics , ecology , physics , induced pluripotent stem cell , quantum mechanics , gene

The molecular mechanisms of self-organization that orchestrate embryonic cells to create astonishing patterns have been among major questions of developmental biology. It is recently shown that embryonic stem cells (ESCs), when cultured in particular micropatterns, can self-organize and mimic the early steps of pre-implantation embryogenesis. A systems-biology model to address this observation from a dynamical systems perspective is essential and can enhance understanding of the phenomenon.

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