CMEP: a database for circulating microRNA expression profiling | Zendy

Jianrong Li | Zendy; Chun-Yip Tong | Zendy; Tsai-Jung Sung | Zendy; Tingyu Kang | Zendy; Xianghong Jasmine Zhou | Zendy; Chun-Chi Liu | Zendy

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CMEP: a database for circulating microRNA expression profiling

Author(s) -

Jianrong Li,

Chun-Yip Tong,

Tsai-Jung Sung,

Tingyu Kang,

Xianghong Jasmine Zhou,

Chun-Chi Liu

Publication year - 2019

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btz042

Subject(s) - microrna , computational biology , function (biology) , profiling (computer programming) , computer science , biology , gene , genetics , operating system

In recent years, several experimental studies have revealed that the microRNAs (miRNAs) in serum, plasma, exosome and whole blood are dysregulated in various types of diseases, indicating that the circulating miRNAs may serve as potential noninvasive biomarkers for disease diagnosis and prognosis. However, no database has been constructed to integrate the large-scale circulating miRNA profiles, explore the functional pathways involved and predict the potential biomarkers using feature selection between the disease conditions. Although there have been several studies attempting to generate a circulating miRNA database, they have not yet integrated the large-scale circulating miRNA profiles or provided the biomarker-selection function using machine learning methods.

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