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MULTiPly: a novel multi-layer predictor for discovering general and specific types of promoters
Author(s) -
Meng Zhang,
Fuyi Li,
Tatiana T. MarquezLago,
André Leier,
Cunshuo Fan,
Chee Keong Kwoh,
KuoChen Chou,
Jiangning Song,
Cangzhi Jia
Publication year - 2019
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btz016
Subject(s) - promoter , benchmarking , computer science , benchmark (surveying) , feature (linguistics) , feature selection , jackknife resampling , data mining , computational biology , artificial intelligence , machine learning , biology , gene , genetics , mathematics , statistics , gene expression , linguistics , philosophy , geodesy , marketing , estimator , business , geography
Promoters are short DNA consensus sequences that are localized proximal to the transcription start sites of genes, allowing transcription initiation of particular genes. However, the precise prediction of promoters remains a challenging task because individual promoters often differ from the consensus at one or more positions.

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