Phylogenetic approaches to identifying fragments of the same gene, with application to the wheat genome
Author(s) -
Ivana Piližota,
Clément-Marie Train,
Adrian Altenhoff,
Henning Redestig,
Christophe Dessimoz
Publication year - 2018
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bty772
Subject(s) - ensembl , genome , phylogenetic tree , sequence assembly , biology , gene , computational biology , gene prediction , reference genome , genomics , genetics , computer science , transcriptome , gene expression
As the time and cost of sequencing decrease, the number of available genomes and transcriptomes rapidly increases. Yet the quality of the assemblies and the gene annotations varies considerably and often remains poor, affecting downstream analyses. This is particularly true when fragments of the same gene are annotated as distinct genes, which may cause them to be mistaken as paralogs.
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