LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics | Zendy

Eoin Fahy | Zendy; Jorge Álvarez-Jarreta | Zendy; Christopher J. Brasher | Zendy; An Nguyen | Zendy; Jade I. Hawksworth | Zendy; Patrícia Rodrigues | Zendy; Sven W. Meckelmann | Zendy; Stuart M. Allen | Zendy; Valerie B. O’Donnell | Zendy

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LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics

Author(s) -

Eoin Fahy,

Jorge Álvarez-Jarreta,

Christopher J. Brasher,

An Nguyen,

Jade I. Hawksworth,

Patrícia Rodrigues,

Sven W. Meckelmann,

Stuart M. Allen,

Valerie B. O’Donnell

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty679

Subject(s) - lipidomics , workflow , computer science , interface (matter) , statistical analysis , set (abstract data type) , data mining , search engine , information retrieval , database , bioinformatics , operating system , statistics , biology , mathematics , bubble , maximum bubble pressure method , programming language

We present LipidFinder online, hosted on the LIPID MAPS website, as a liquid chromatography/mass spectrometry (LC/MS) workflow comprising peak filtering, MS searching and statistical analysis components, highly customized for interrogating lipidomic data. The online interface of LipidFinder includes several innovations such as comprehensive parameter tuning, a MS search engine employing in-house customized, curated and computationally generated databases and multiple reporting/display options. A set of integrated statistical analysis tools which enable users to identify those features which are significantly-altered under the selected experimental conditions, thereby greatly reducing the complexity of the peaklist prior to MS searching is included. LipidFinder is presented as a highly flexible, extensible user-friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAPS website, long recognized as a leading global lipidomics portal.

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