SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation | Zendy

Justina Jankauskaitė | Zendy; Brian JiménezGarcía | Zendy; Justas Dapkūnas | Zendy; Juan FernándezRecio | Zendy; Iain H. Moal | Zendy

Open Access

SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation

Author(s) -

Justina Jankauskaitė,

Brian JiménezGarcía,

Justas Dapkūnas,

Juan FernándezRecio,

Iain H. Moal

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty635

Subject(s) - kinetics , mutation , protein data bank , enthalpy , binding energy , computational biology , entropy (arrow of time) , chemistry , thermodynamics , protein structure , biology , biochemistry , physics , gene , quantum mechanics , nuclear physics

Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which mutations lead to disease, and protein engineering.

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