Crumble: reference free lossy compression of sequence quality values | Zendy

James Bonfield | Zendy; Shane McCarthy | Zendy; Richard Durbin | Zendy

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Crumble: reference free lossy compression of sequence quality values

Author(s) -

James Bonfield,

Shane McCarthy,

Richard Durbin

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty608

Subject(s) - computer science , file size , database , lossy compression , file format , quality (philosophy) , set (abstract data type) , base (topology) , reduction (mathematics) , compression (physics) , sequence (biology) , data mining , operating system , mathematics , programming language , biology , mathematical analysis , philosophy , materials science , geometry , epistemology , composite material , genetics

The bulk of space taken up by NGS sequencing CRAM files consists of per-base quality values. Most of these are unnecessary for variant calling, offering an opportunity for space saving.

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