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Kinome-wide identification of phosphorylation networks in eukaryotic proteomes
Author(s) -
Luca Parca,
Bruno Ariano,
Andrea Cabibbo,
Marco Paoletti,
Annalaura Tamburrini,
Antonio Palmeri,
Gabriele Ausiello,
Manuela HelmerCitterich
Publication year - 2018
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bty545
Subject(s) - kinome , computational biology , kinase , proteome , identification (biology) , phosphorylation , biology , computer science , bioinformatics , biochemistry , botany
Signaling and metabolic pathways are finely regulated by a network of protein phosphorylation events. Unraveling the nature of this intricate network, composed of kinases, target proteins and their interactions, is therefore of crucial importance. Although thousands of kinase-specific phosphorylations (KsP) have been annotated in model organisms their kinase-target network is far from being complete, with less studied organisms lagging behind.

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