Differential coexpression in human tissues and the confounding effect of mean expression levels | Zendy

Marjan Farahbod | Zendy; Paul Pavlidis | Zendy

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Differential coexpression in human tissues and the confounding effect of mean expression levels

Author(s) -

Marjan Farahbod,

Paul Pavlidis

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty538

Subject(s) - confounding , biology , differential (mechanical device) , gene expression , gene , expression (computer science) , differential diagnosis , gene expression profiling , computational biology , genetics , medicine , computer science , pathology , engineering , programming language , aerospace engineering

Differential coexpression-the alteration of gene coexpression patterns observed in different biological conditions-has been proposed to be a mechanism for revealing rewiring of transcription regulatory networks. Despite wide use of methods for differential coexpression analysis, the phenomenon has not been well-studied. In particular, in many applications, differential coexpression is confounded with differential expression, that is, changes in average levels of expression across conditions. This confounding, despite affecting the interpretation of the differential coexpression, has rarely been studied.

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