Unraveling the role of low-frequency mutated genes in breast cancer | Zendy

Eleonora Lusito | Zendy; Barbara Felice | Zendy; Dario Giorgini | Zendy; Alessandro G. E. Ogier | Zendy; Francesca Montani | Zendy; Pier Paolo Di Fiore | Zendy; Fabrizio Bianchi | Zendy

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Unraveling the role of low-frequency mutated genes in breast cancer

Author(s) -

Eleonora Lusito,

Barbara Felice,

Dario Giorgini,

Alessandro G. E. Ogier,

Francesca Montani,

Pier Paolo Di Fiore,

Fabrizio Bianchi

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty520

Subject(s) - breast cancer , gene , genetics , biology , mutation , computational biology , cancer

Breast cancer is the most commonly diagnosed malignancy in women and the second cause of cancer death in developed countries. While advancements in early detection and therapeutic options have led to a significant decrease in mortality, response to treatment is affected by the genetic heterogeneity of the disease. Recent genome-wide DNA mutation analyses revealed the existence of hundreds of low-frequency mutated genes, in addition to known cancer drivers: a finding that is prompting research into the impact of these genes on the pathogenesis of the disease.

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