SONiCS: PCR stutter noise correction in genome-scale microsatellites | Zendy

Katarzyna Kedzierska | Zendy; Livia Gerber | Zendy; Daniele Cagnazzi | Zendy; Michael Krützen | Zendy; Aakrosh Ratan | Zendy; Logan Kistler | Zendy

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SONiCS: PCR stutter noise correction in genome-scale microsatellites

Author(s) -

Katarzyna Kedzierska,

Livia Gerber,

Daniele Cagnazzi,

Michael Krützen,

Aakrosh Ratan,

Logan Kistler

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty485

Subject(s) - microsatellite , genotyping , computer science , population , genetics , computational biology , biology , genotype , allele , gene , medicine , environmental health

Massively parallel capture of short tandem repeats (STRs, or microsatellites) provides a strategy for population genomic and demographic analyses at high resolution with or without a reference genome. However, the high Polymerase Chain Reaction (PCR) cycle numbers needed for target capture experiments create genotyping noise through polymerase slippage known as PCR stutter.

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