Predicting clone genotypes from tumor bulk sequencing of multiple samples | Zendy

Sayaka Miura | Zendy; Karen Gomez | Zendy; Oscar Murillo | Zendy; Louise A. Huuki-Myers | Zendy; Tracy Vu | Zendy; Tiffany Buturla | Zendy; Sudhir Kumar | Zendy

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Predicting clone genotypes from tumor bulk sequencing of multiple samples

Author(s) -

Sayaka Miura,

Karen Gomez,

Oscar Murillo,

Louise A. Huuki-Myers,

Tracy Vu,

Tiffany Buturla,

Sudhir Kumar

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty469

Subject(s) - clone (java method) , genotype , computational biology , biology , dna sequencing , genetics , gene

Analyses of data generated from bulk sequencing of tumors have revealed extensive genomic heterogeneity within patients. Many computational methods have been developed to enable the inference of genotypes of tumor cell populations (clones) from bulk sequencing data. However, the relative and absolute accuracy of available computational methods in estimating clone counts and clone genotypes is not yet known.

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