Predicting Cancer Drug Response using a Recommender System
Author(s) -
Chayaporn Suphavilai,
Denis Bertrand,
Niranjan Nagarajan
Publication year - 2018
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bty452
Subject(s) - recommender system , computer science , drug response , cancer , drug , cancer drugs , information retrieval , medicine , pharmacology
As we move toward an era of precision medicine, the ability to predict patient-specific drug responses in cancer based on molecular information such as gene expression data represents both an opportunity and a challenge. In particular, methods are needed that can accommodate the high-dimensionality of data to learn interpretable models capturing drug response mechanisms, as well as providing robust predictions across datasets.
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