Base-pair resolution detection of transcription factor binding site by deep deconvolutional network | Zendy

Sirajul Salekin | Zendy; Jianqiu Michelle Zhang | Zendy; Yufei Huang | Zendy

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Base-pair resolution detection of transcription factor binding site by deep deconvolutional network

Author(s) -

Sirajul Salekin,

Jianqiu Michelle Zhang,

Yufei Huang

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty383

Subject(s) - transcription factor , binding site , computer science , base (topology) , dna binding site , resolution (logic) , computational biology , transcription (linguistics) , artificial intelligence , genetics , biology , promoter , gene , gene expression , mathematics , mathematical analysis , linguistics , philosophy

Transcription factor (TF) binds to the promoter region of a gene to control gene expression. Identifying precise TF binding sites (TFBSs) is essential for understanding the detailed mechanisms of TF-mediated gene regulation. However, there is a shortage of computational approach that can deliver single base pair resolution prediction of TFBS.

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