A comprehensive web tool for toehold switch design | Zendy

Andrew Ching-Yuet To | Zendy; David H. Chu | Zendy; Angela Ruoning Wang | Zendy; Frances Cheuk-Yau Li | Zendy; Alan Wai-On Chiu | Zendy; Daisy Yuwei Gao | Zendy; Chung Hang Jonathan Choi | Zendy; SiuKai Kong | Zendy; TingFung Chan | Zendy; King Ming Chan | Zendy; Kevin Y. Yip | Zendy

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A comprehensive web tool for toehold switch design

Author(s) -

Andrew Ching-Yuet To,

David H. Chu,

Angela Ruoning Wang,

Frances Cheuk-Yau Li,

Alan Wai-On Chiu,

Daisy Yuwei Gao,

Chung Hang Jonathan Choi,

SiuKai Kong,

TingFung Chan,

King Ming Chan,

Kevin Y. Yip

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty216

Subject(s) - computer science , software , programming language

Toehold switches are a class of RNAs with a hairpin loop that can be unfolded upon binding a trigger RNA, thereby exposing a ribosome binding site (RBS) and permitting translation of the reporter protein. They have been shown very useful in detecting a variety of targets including RNAs from Zika and Ebola viruses. The base complementation between the toehold switch and the trigger RNA also makes it sensitive to sequence variations. Design of toehold switches involves a series of considerations related to their sequence properties, structures and specificities.

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