ASGART: fast and parallel genome scale segmental duplications mapping | Zendy

Franklin Delehelle | Zendy; Sylvain CussatBlanc | Zendy; JeanMarc Alliot | Zendy; Hervé Luga | Zendy; Patricia Balaresque | Zendy

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ASGART: fast and parallel genome scale segmental duplications mapping

Author(s) -

Franklin Delehelle,

Sylvain CussatBlanc,

JeanMarc Alliot,

Hervé Luga,

Patricia Balaresque

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty172

Subject(s) - segmental duplication , genome , computer science , adaptability , computational biology , biology , software , source code , whole genome sequencing , dna sequencing , genetics , dna , gene , programming language , ecology , gene family

Segmental Duplications (SDs) are DNA fragments longer than 1 kbp, distributed within and between chromosomes and sharing more than 90% identity. Although they hold a significant role in genomic fluidity and adaptability, many key questions about their intrinsic characteristics and mutability remain unsolved due to the persistent difficulty of sequencing highly duplicated genomic regions. The recent development of long and linked-read NGS technologies will increase the need to search for SDs in genomes newly sequenced with these technics. The main limitation of SD analysis will soon be the availability of efficient detection software, to retrieve and compare SD genomic component between species or lineages.

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