Design tools for MPRA experiments | Zendy

Andrew R. Ghazi | Zendy; Edward S. Chen | Zendy; David Henke | Zendy; Namrata Madan | Zendy; Leonard C. Edelstein | Zendy; Chad A. Shaw | Zendy

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Design tools for MPRA experiments

Author(s) -

Andrew R. Ghazi,

Edward S. Chen,

David Henke,

Namrata Madan,

Leonard C. Edelstein,

Chad A. Shaw

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty150

Subject(s) - computer science , upload , construct (python library) , throughput , computational biology , operating system , biology , programming language , wireless

Genetic reporter assays are a convenient, relatively inexpensive method for studying the regulation of gene expression. Massively Parallel Reporter Assays (MPRA) are high-throughput functionalization assays that interrogate the transcriptional activity of many genetic variants at once using a library of synthetic barcoded constructs. Despite growing interest in this area, there are few computational tools to design and execute MPRA studies.

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