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Chromatin immunoprecipitation followed by sequencing (ChIP-seq) can detect read-enriched DNA loci for point-source (e.g. transcription factor binding) and broad-source factors (e.g. various histone modifications). Although numerous quality metrics for ChIP-seq data have been developed, the 'peaks' thus obtained are still difficult to assess with respect to signal-to-noise ratio (S/N) and the percentage of false positives.

Sensitive and robust assessment of ChIP-seq read distribution using a strand-shift profile