Open AccessCRISPR-DT: designing gRNAs for the CRISPR-Cpf1 system with improved target efficiency and specificity
Author(s) -
Houxiang Zhu,
Chun Liang
Publication year - 2019
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bty1061
Subject(s) - crispr , computer science , computational biology , guide rna , trans activating crrna , genome editing , biology , genetics , gene
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cpf1 system has been successfully applied in genome editing. However, target efficiency of the CRISPR-Cpf1 system varies among different guide RNA (gRNA) sequences.
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