Open AccessFWER and FDR control when testing multiple mediators
Author(s) -
Joshua N. Sampson,
Simina M. Boca,
Steven C. Moore,
Ruth Heller
Publication year - 2018
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bty064
Subject(s) - control (management) , computer science , false discovery rate , multiple comparisons problem , statistics , artificial intelligence , mathematics , biology , genetics , gene
The biological pathways linking exposures and disease risk are often poorly understood. To gain insight into these pathways, studies may try to identify biomarkers that mediate the exposure/disease relationship. Such studies often simultaneously test hundreds or thousands of biomarkers.
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