A low-complexity add-on score for protein remote homology search with COMER | Zendy

Mindaugas Margelevičius | Zendy

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A low-complexity add-on score for protein remote homology search with COMER

Author(s) -

Mindaugas Margelevičius

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty048

Subject(s) - computer science , software , data mining , sequence alignment , sensitivity (control systems) , multiple sequence alignment , machine learning , bioinformatics , programming language , peptide sequence , biology , biochemistry , gene , electronic engineering , engineering

Protein sequence alignment forms the basis for comparative modeling, the most reliable approach to protein structure prediction, among many other applications. Alignment between sequence families, or profile-profile alignment, represents one of the most, if not the most, sensitive means for homology detection but still necessitates improvement. We aim at improving the quality of profile-profile alignments and the sensitivity induced by them by refining profile-profile substitution scores.

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