A network approach to exploring the functional basis of gene–gene epistatic interactions in disease susceptibility | Zendy

Danny Kit-Sang Yip | Zendy; Landon L. Chan | Zendy; Iris Pang | Zendy; Wei Jiang | Zendy; Nelson L.S. Tang | Zendy; Weichuan Yu | Zendy; Kevin Y. Yip | Zendy

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A network approach to exploring the functional basis of gene–gene epistatic interactions in disease susceptibility

Author(s) -

Danny Kit-Sang Yip,

Landon L. Chan,

Iris Pang,

Wei Jiang,

Nelson L.S. Tang,

Weichuan Yu,

Kevin Y. Yip

Publication year - 2018

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bty005

Subject(s) - epistasis , gene , genetics , computational biology , basis (linear algebra) , biology , disease , gene interaction , gene regulatory network , gene expression , medicine , mathematics , pathology , geometry

Individual genetic variants explain only a small fraction of heritability in some diseases. Some variants have weak marginal effects on disease risk, but their joint effects are significantly stronger when occurring together. Most studies on such epistatic interactions have focused on methods for identifying the interactions and interpreting individual cases, but few have explored their general functional basis. This was due to the lack of a comprehensive list of epistatic interactions and uncertainties in associating variants to genes.

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