gene2drug: a computational tool for pathway-based rational drug repositioning | Zendy

Francesco Napolitano | Zendy; Diego Carrella | Zendy; Barbara Mandriani | Zendy; Sandra PisoneroVaquero | Zendy; Francesco Sirci | Zendy; Diego L. Medina | Zendy; Nicola BrunettiPierri | Zendy; Diego di Bernardo | Zendy

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gene2drug: a computational tool for pathway-based rational drug repositioning

Author(s) -

Francesco Napolitano,

Diego Carrella,

Barbara Mandriani,

Sandra PisoneroVaquero,

Francesco Sirci,

Diego L. Medina,

Nicola BrunettiPierri,

Diego di Bernardo

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx800

Subject(s) - tfeb , drug repositioning , drug discovery , computational biology , in silico , nrf1 , transcription factor , computer science , drug , regulator , biology , bioinformatics , gene , pharmacology , genetics

Drug repositioning has been proposed as an effective shortcut to drug discovery. The availability of large collections of transcriptional responses to drugs enables computational approaches to drug repositioning directly based on measured molecular effects.

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