The OncoPPi Portal: an integrative resource to explore and prioritize protein–protein interactions for cancer target discovery | Zendy

Andrei A. Ivanov | Zendy; Brian Revennaugh | Zendy; Lauren Rusnak | Zendy; Valentina González-Pecchi | Zendy; Xiulei Mo | Zendy; Margaret A. Johns | Zendy; Yuhong Du | Zendy; Lee Cooper | Zendy; Carlos S. Moreno | Zendy; Fadlo R. Khuri | Zendy; Haian Fu | Zendy

Open Access

The OncoPPi Portal: an integrative resource to explore and prioritize protein–protein interactions for cancer target discovery

Author(s) -

Andrei A. Ivanov,

Brian Revennaugh,

Lauren Rusnak,

Valentina González-Pecchi,

Xiulei Mo,

Margaret A. Johns,

Yuhong Du,

Lee Cooper,

Carlos S. Moreno,

Fadlo R. Khuri,

Haian Fu

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx743

Subject(s) - druggability , identification (biology) , computational biology , cancer , context (archaeology) , uniprot , drug discovery , computer science , bioinformatics , biology , gene , genetics , botany , paleontology

As cancer genomics initiatives move toward comprehensive identification of genetic alterations in cancer, attention is now turning to understanding how interactions among these genes lead to the acquisition of tumor hallmarks. Emerging pharmacological and clinical data suggest a highly promising role of cancer-specific protein-protein interactions (PPIs) as druggable cancer targets. However, large-scale experimental identification of cancer-related PPIs remains challenging, and currently available resources to explore oncogenic PPI networks are limited.

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